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Notes Wednesday: Sunday Edition

the Drug War Philosopher speaks out on Treatment Resistant Depression Day, ayahuasca-related deaths, and William James and religious freedom

by Brian Ballard Quass, the Drug War Philosopher

October 18, 2026



It seemed too good to be true. I ran across an informative essay by a certain Dmitri DmiTymoczko this afternoon entitled "The Nitrous Oxide Philosopher" published in the Atlantic in 19961. Finally, an article that discussed the religious implications of James's work! And what's more, I found that the author was still alive and well and reachable at a readily available contact address. "Finally," I thought to myself, "here is somebody with whom my arguments should resonate regarding William James and the way his legacy has been dishonored by the academic community. Here is someone who is not going to dismiss me out of hand since he himself broaches some of the topics with which I have dealt in depth these last seven years now and in which I have a personal stake!" So thinking, I concocted a paragraph-length email to send to Dmitri in order to apprise him of my situation and to invite him to read my latest super-relevant essay on this topic2, in which I felt he simply had to be interested given what he had written. True, he wrote his piece two decades ago, but Dmitri would surely be interested in a new angle on the topic, especially when I explained to him how America's failure to take William James seriously about health care has helped turn me into a ward of the healthcare state.

Vain hope.

Dmitri got back to me within a few hours, politely admonishing me that his article on James was written a long time ago and that the psychologist feels far away from him now. He says he has written almost endlessly since then, but mostly about music -- which makes sense, of course, given that subsequent research reveals Dmitri to be a professor of music at Princeton University. He did close his three-sentence reply to me, however, by providing me with a ray of hope, albeit a very pale, slim and equivocal ray. He tells me that he is "veering back" to philosophy... which, of course, is probably just meant as a parenthetical autobiographical titbit on his part, but it could also be interpreted -- especially if the reader were desperate for good news -- as an attempt to incite me to give him still more reasons to come out of retirement on the philosophical front. Normally, I read such responses as telling me to "buzz off" and I promptly do so, without so much as pestering my correspondent with a reply, but the addition of that slightly equivocal third sentence of his about "veering off" toward philosophy emboldened me to respond as follows.

"Well, if you ever veer further, let me know. I'm still looking for another philosopher who cares that William James' legacy with nitrous oxide is being ignored -- and I care because the results of that censorship have had negative effects in my own life."

I fear that replying in this way was just a hair's breadth short of presumptuous, but I must own that I was surprised to learn that anyone's interest in the issues raised by William James regarding nitrous oxide -- and especially those that Dmitri had raised about religious liberty -- could have an expiration date. But then it has been 20 years, hasn't it? Well, you know what they say: live and learn... or in this case, live and become increasingly surprised at the totally unexpected responses that one's best efforts elicit in this world.

Fortunately, I don't have time to feel sorry for myself today because it is Notes Wednesday, the time when I publish responses to notes that have appeared on my Substack feed. It's actually Sunday today, of course, but I can ignore that technicality. That's one of the perks of having a vanishingly small readership.

Irritation Level: high
FROM: Jules Evan
NOTE:
CAPTION: Serious harms and a death at the Ayahuasca Foundation (beneath picture of seemingly 'native-garbed' celebrants with blurred faces)
COMMENT:
All it takes is one single death to make Americans call for drug prohibition. Meanwhile, there are 47,000 gun-related deaths per year and 178,000 alcohol-related deaths, and no one blames either guns or alcohol. It is drug prohibition that makes life dangerous because it discourages drug education and teaches intolerance and fear instead. Julian might as well have posted a picture of people having fun in a bar with the caption: “Serious harms and a death at a local bar.”


Irritation Level: high
FROM: Jules Evans
NOTE:
Its Treatment Resistant Depression (TRD) Awareness Day. Amazing how this mental disorder is given its own day, just as pharmaceutical companies launch billion-dollar products to treat it (ketamine, psilocybin etc) . What does TRD mean? It means ‘our previous products did not work as advertized, here are some new products’. Like the previous products, they will work for some, not for everyone, and adverse events are already being minimized / hidden.
COMMENT:
As a med-dependent patient who has to see a doctor one-third his age every three months of my life, I hate the term “treatment-resistant depression.” It suggests that science has “solved” depression but that there are a few weirdos out there whose body’s don’t recognize a good thing when they see it. We need to end drug prohibition before we can decide who — if anyone — REALLY has a treatment-resistant depression. We need to re-legalize Mother Nature and restore our individual right to take care of our own health.


Irritation Level: medium
FROM: Sarah
NOTE:
Dr Nolan Williams ended his life last year as a result of it (i.e., depression). Apparently he didn’t try ibogaine, though he studied it…
COMMENT:
It’s beyond a bad joke. Drug prohibition outlaws all substances that inspire and elate. We Americans would rather have suicide than drug use. The proof is extant. Our ethicists today debate the possibility of drug-aided suicide for the depressed — without mentioning the fact that we’ve outlawed all drugs that could make the depressed wish to live. Such drugs abound, and many are nonaddictive — but surely even dependence and addiction are better than death — especially in a country where 1 in 4 women take a psychiatric med every day of their life (source: Julie Holland).


Irritation Level: high
FROM: Justin Garson
NOTE:
Post on The Ethics of Disrupting Science
COMMENT:
In the late 19th and early 20th centuries, there was a debate about attempting to suppress quack cures-- a debate dominated by self-interested physicians. The problem is that by "quack cures," physicians back then meant any health treatment that did not treat the human being as a biochemical widget. William James tried to push back against this way of conceiving of health care, but he was outnumbered, outspent and outvoted by self-interested doctors. This goes a long way toward explaining where we are at today with drug prohibition and the psychiatric pill mill. We definitely need to disrupt this kind of "science." The best way would be to end drug prohibition, which outlaws the rights of the depressed to heal, meanwhile turning them into wards of the healthcare state by placing them on "meds" that are harder to kick than heroin. I write from personal hard-earned experience on this topic. I am a 68-year-old who has to see a doctor one-third my age every three months of his life for a refill on a dependence-causing med, meanwhile answering humiliating questions like, "Do you hear voices?" Drug prohibition has turned me into an eternal patient and an eternal child.


Irritation Level: medium
FROM: Justin Garson
NOTE:
In response to comment by Dr. Roger McFillin about self-medicating on the substack of Justin Garson.
COMMENT:
As Thomas Szasz points out, self-medicating has always been a basic right. It is simply the right to take care of one’s own health. It’s amazing that no one sees the self-interest that doctors have in depicting self-medication as a sin. Doctors also have a self-interest in claiming that there aren’t any benefits to “drugs,” that we need a “real” cure (preferably a dependence-causing cure that will turn us into a ward of the healthcare state). They don’t want humans treating themselves. When police arrest us for drug use, they are really arresting us for taking care of our own health without doctors. Police are enforcing a monopoly.










Notes for essay entitled Notes Wednesday: Sunday Edition: the Drug War Philosopher speaks out on Treatment Resistant Depression Day, ayahuasca-related deaths, and William James and religious freedom:

1: Tymoczko, Dmitri. 1996 “The Nitrous Oxide Philosopher.” General_Anesthesia.Com. general_anesthesia.com. Accessed October 18, 2026. (up)
2: When legislators take sides in scientific disputes DWP (up)




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Ten Tweets

against the hateful war on US




The Hindu religion was created thanks to the use of a drug that inspired and elated. It is therefore a crime against religious liberty to outlaw substances that inspire and elate.

What are drug dealers doing, after all? They are merely selling substances that people want and have always had a right to, until racist politicians came along and decided government had the right to ration out pain relief and mystical experience.

"The Legislature deliberately determines to distrust the very people who are legally responsible for the physical well-being of the nation, and puts them under the thumb of the police, as if they were potential criminals." -- Aleister Crowley on drug laws

The drug war controls the very way that we are allowed to see the world. The Drug War is thus a meta-injustice, not just a handful of bad legal statutes.

The Drug War is a crime against humanity.

Guess who's in charge of protecting us from AI? Chuck Schumer! The same guy who protected us from drugs -- by turning America into a prison camp full of minorities and so handing two presidential elections to Donald Trump.

Most psychoactive substance use can be judged as recreational OR medicinal OR both. The judgements are not just determined by the circumstances of use, either, but also by the biases of those doing the judging.

When Rick Strassman and Michael Pollan call for continued prohibition to protect young people, they ignore the ENORMOUS fact that prohibition has destroyed inner cities around the world. Wake up, guys! Prohibition is evil, not drugs! Ignorance is evil, not education!

Healthline posted an article in 2021 about the benefits of getting off of antidepressants. They did not even mention the biggest benefit: NO LONGER BEING AN ETERNAL PATIENT -- no longer being a child in the eyes of an all-knowing healthcare system.

I thought mycology clubs across the US would be protesting drug laws that make mushroom collecting illegal for psychoactive species. But in reality, almost no club even mentions such species. No wonder prohibition is going strong.


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